Lymphangioleiomyomatosis (LAM) is a rare lung disease found primarily in women and often affects other organs including lymph nodes and kidneys. LAM is caused by inactivating mutations in the tuberous sclerosis complex (TSC) genes (TSC1 and TSC2), resulting in activation of the mammalian target of rapamycin (mTOR) complex 1 (TORC1) signaling network. LAM can occur […]