LAM Therapeutics Closes $40M in Financing and Announces Two Clinical-Stage Programs in Rare Diseases and Cancer

Bringing the total raised for the current class of 4Catalyzer companies to a quarter-billion dollars

GUILFORD, Conn. –Feb. 2, 2016– LAM Therapeutics closed a $40 million financing to accelerate the development of therapeutics for the treatment of rare diseases and cancer. LAM Therapeutics is a 4Catalyzer company. 4Catalyzer is Connecticut’s premier biotechnology startup incubator and with this financing has raised a total of a quarter billion dollars to support its current class of startups.

LAM Therapeutics leverages Next Gen sequencing, advances in genome editing, computer science and artificial intelligence to discover and develop medicines faster, with more precision and at a lower cost than conventional approaches.

“Spending a decade and a billion dollars to bring a drug to market is not consistent with global healthcare needs,” said Dr. Jonathan Rothberg, co-founder of LAM Therapeutics. “We built LAM Therapeutics from the ground up to transform the way we develop medicines. We are at an inflection point; DNA sequencing and computer science have both advanced over a million fold since our first attempts to create true genomics-based medicines.  Now is the time to tackle our greatest challenges, including rare diseases and cancer, and we have the technological and computation power to get the job done.”

Dr. Rothberg is best known for inventing and bringing to market the first “Next Gen” or high-speed, DNA sequencing technology, for which he is being awarded the 2016 Medal of Technology and Innovation by President Obama this spring. To achieve his vision for LAM Therapeutics, Dr. Rothberg has brought together a unique team with deep experience in genomics, computational biology, AI, and drug development.

“We bring together teams to do things no one has done before and to produce products that someday could save the life of somebody you love,” said Dr. Rothberg. “We are always looking for gifted people to join 4Catalyzer companies. If you make chips like Gordon Moore, lasers like Charles Townes, or break codes like Hedy Lamarr, come join us.”

LAM’s technologies include genome-editing methods developed by LAM co-founder Dr. Tian Xu, a world leader in genome engineering, Vice Chair of Genetics at the Yale School of Medicine and a Howard Hughes Medical Institute Investigator. “We are delighted that we were able to quickly bring two precision medicines into the clinic by combining Dr. Rothberg’s decades of expertise in DNA sequencing and Professor Xu’s experience in genome engineering,” said Dr. Henri Lichenstein, co-founder and President of LAM. “Their expertise in reading and writing genomes, when enabled with leading-edge computer science, allows us to find the best targets, identify appropriate patients, and create predictive diagnostics for our therapeutics.”
LAM Therapeutics’ clinical stage drugs include:

LAM-001 – The first inhaled mTOR inhibitor in Phase 1 clinical development for lymphangioleiomyomatosis and related indications.

LAM-002 – An exquisitely selective kinase inhibitor in Phase 1 clinical development for relapsed or refractory non-Hodgkin B-cell lymphoma.

Each trial is designed to assess the safety and tolerability of the drugs and follows acceptance of an Investigational New Drug (IND) application by the U.S. Food and Drug Administration (FDA).

About LAM Therapeutics
LAM Therapeutics develops drugs for rare diseases and cancer.  LAM takes advantage of the inflection point in biological understanding and computer science, leveraging big data from Next Gen sequencing, genome editing, chemical genomics, and combinational drug screening, to develop precision therapeutics and companion diagnostics. LAM has advanced two drugs into the clinic: LAM-001 for lymphangioleiomyomatosis, and LAM-002 for B-cell non-Hodgkin lymphoma.

About 4Catalyzer
4Catalyzer is a startup accelerator dedicated to transforming 21st century medicine by solving the most challenging problems in the life sciences and medicine. 4Catalyzer companies develop breakthrough therapeutics or sensors, and pair them with deep learning (AI) to enable a unique window into biology and medicine. 4Catalyzer is driven by the desire to develop products that will significantly improve the lives of people we love.

For more information contact:
Wes Conard, 4Catalyzer
Head of Marketing + Communications
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LAM Therapeutics launches operations to develop drugs for rare lung disease, Lymphangioleiomyomatosis (LAM)

Company is first to focus on developing drugs for Lymphangioleiomyomatosis

Guilford, CT – June 6, 2013 – LAM Therapeutics, the first biopharmaceutical company dedicated to identifying and developing drugs for the treatment of Lymphangioleiomyomatosis (LAM), announced today that it has closed a Series A financing with private investors to launch operations. Proceeds from the financing will be used for identification of clinical stage drugs with potential activity against LAM and to conduct clinical trials.

LAM is a rare lung disease found primarily in women. Besides the lungs, LAM often affects other organs including lymph nodes and kidneys. LAM is characterized as a destructive, metastasizing neoplasm of smooth muscle-like cells that leads to progressive cystic lung disease. The disorder causes shortness of breath, lung destruction, respiratory failure and death.

LAM originates from mutations in tuberous sclerosis complex (TSC) genes, resulting in the aberrant activation of the mammalian target of rapamycin (mTOR) complex 1 signaling network, which is also activated in the majority of human cancers. LAM can occur in otherwise healthy women (sporadic LAM) or in women who have TSC, a genetic disease associated with benign tumors of the brain, heart, skin and kidneys. Currently, there is no cure or FDA-approved drug for LAM.

Leading LAM Therapeutics as President and CSO is veteran drug developer Henri Lichenstein, Ph. D, who has held leadership positions at Amgen, CuraGen, Topotarget and BioPontis Alliance. The initial members of the LAM Therapeutics Scientific Advisory Board are Drs. Brendan Manning and Robert Spiegel. Dr. Brendan Manning is a leading researcher in mTOR signaling, TSC and LAM. He is a Professor in the Department of Genetics and Complex Diseases at the Harvard School of Public Health and obtained his Ph.D. at Yale University. Dr. Spiegel has greater than 25 years of experience in the pharmaceutical industry, having played a significant role in the development of novel drugs as Senior VP of Worldwide Clinical Research and Chief Medical Officer at Schering-Plough. Dr. Spiegel obtained his M.D. from the University of Pennsylvania and a B.A. cum laude from Yale University.

“LAM is devastating to women that are of child-bearing age and older. New breakthrough drugs to treat and cure LAM will serve an unmet medical need. LAM Therapeutics is a product-focused company that will use an outsourced model of drug development. A superb network of advisors, contract research organizations, academic collaborators, patient advocate organizations and consultants will be utilized by LAM Therapeutics”, said Henri Lichenstein.

“I look forward to working with LAM Therapeutics and helping to establish innovative screens that identify single agent and combination drugs that target the specific vulnerabilities of LAM cells to selectively eradicate these cells from LAM patients. Understanding the vulnerability that accompanies the proliferative and metastatic behavior of LAM cells may prove key to developing treatments for other cancers”, said Dr. Brendan Manning.

“As new drugs are identified to treat LAM, I am delighted to aid LAM Therapeutics in the advancement of these agents through clinical development”, said Dr. Robert Spiegel.


Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. serves as legal counsel to LAM Therapeutics.

About LAM Therapeutics

LAM Therapeutics is the first biopharmaceutical company dedicated to identifying and developing drugs for the treatment of Lymphangioleiomyomatosis (LAM). LAM Therapeutics will use novel screening approaches to discover single agent or combination clinical stage drugs with potential to treat LAM. These drugs will be tested by conducting clinical trials in LAM patients. The primary focus of LAM Therapeutics is to develop drugs that provide long-lasting responses or remissions, thus improving length and quality of life for LAM patients. Because misregulated pathways in LAM cells may also be found in cancer cells, active drugs identified by LAM Therapeutics have the potential to be used in the treatment of other cancers. LAM Therapeutics is located in Guilford, CT. For more information, please visit the company’s website at